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ôWas there some way to break tolerance to hepatitis B by stimulating the immune response?ö Tyrrell studied what others were attempting and wasnÆt satisfied with the approaches others were taking to stimulate immune response. His ViRexx Medical research team brainstormed about different ways to target the antigen into the dendritic cells. ôThatÆs where we came in with the ChimigenÖ technology,ö Tyrrell said. ôThe dendritic cells have receptors on their surface that will bind the Fc portion of an antibody.ö He pointed out a key feature of the ChimigenÖ platform, ôWe used the Fc portion of a murine (mouse) antibody to hook onto our hepatitis B antigens. This would direct the viral antigens into dendritic cells in vivo.ö Because the dendritic cells are the sentries of the immune system, they guard what comes in. Recognizing a æforeign situationÆ in the murine antibody, it treats the whole molecule including the virus antigen as foreign. LINK RECOGNITION MAY HOLD THE KEY Dr. Rajan George, ViRexx MedicalÆs vice president of research and development, told us, ôThe dendritic cells chop up this protein into small pieces called peptides, also known as epitopes. The dendritic cells have a system where they put the T-cell epitope on another protein, MHC Class I, and bring it to the surface of the dendritic cell. They are presented as a complex on the surface of the dendritic cell to attract the T-cells.ö When the T-cells arrive to inspect the foreign entity, the cytotoxic T-cells are activated. Then, they begin attacking and killing the virus-infected cells. Research at TokyoÆs Cancer Institute Hospital, published in 1987 in Nippon Sanka Fujinka Gakkai Zasshi, suggested a feasibility of linked recognition of a virus antigen as a helper in tumor immunity with a target antigen. In the case of ViRexx Medical, TyrrellÆs team has created a new molecule, called ôchimigen.ö The term is shorthand for a chimeric antigen, meaning it is an antigen created from two different sources, part virus and part murine monoclonal antibody. Dr. TyrrellÆs work at ViRexx Medical with Dr. George suggested the linked-recognition theory might be the key to breaking tolerance. Dr. George emphasized, ôThe new æchimigenÆ stimulates an immune response to the antigen as well as the viral antigen. This is very important because the virus antigen was previously being ignored.ö That brings us back to why lamivudine had limited success. The immune systems of some HBV carriers failed to recognize the viral

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Theodor Bot? Feet Size, Family, Eye Color, fees per movie, Wiki, body stats, Real Name, Profession

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